08.07.2019

Psychosis can be caused by brain structure

Psychosis can be caused by brain structure

Health

Researchers discovered new information about the connection between psychosis and brain. Choroid plexus can be responsible for the illness.

Variations in the structure of the choroid plexus, which produces cerebrospinal fluid (CSF), could play a key role in psychosis.

A team that Dr. Paulo Lizano — of the Beth Israel Deaconess Medical Center in Boston, MA — led has now investigated this vital structure. In doing so, they found that there could be a link between its size and the development of psychosis. The choroid plexus and its product, CSF, are crucial parts of the neurological system. CSF helps cushion the brain within the skull, and the choroid plexus forms a barrier between the brain and the CFS, which helps filter out toxins and keeps blood components from entering the brain. It also allows some molecules to pass through, including those involved with the immune system.

This study — which now appears in the American Journal of Psychiatry — involved three groups of people: participants with a diagnosis of psychosis, one of their first degree relatives, and people with no history of psychosis (the controls).

Each participant underwent a structural MRI brain scan, and the researchers found that the volume of the choroid plexus was larger in those who had psychosis.

They also found that the volume of the choroid plexus among first degree relatives was larger than that of the controls but smaller than that of those with psychosis.

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